Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

J Naidoo, CJ Bemben, SR Allwein, J Liang, AA Pieper…

Index: Naidoo, Jacinth; Bemben, Christopher J.; Allwein, Shawn R.; Liang, Jue; Pieper, Andrew A.; Ready, Joseph M. Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4429 - 4431

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Citation Number: 9

Abstract

Abstract A scalable synthesis of the neuroprotective agent P7C3-A20 is described. The synthesis has provided hundred-gram batches of the final compound for biological evaluation in rodents primates. The synthesis can be performed without chromatographic purification of intermediates or the final product.