Chemical Triple??Mutant Boxes for Quantifying Cooperativity in Intermolecular Interactions

…, PS Jones, P Tiger, S Tomas

Index: Hunter, Christopher A.; Jones, Philip S.; Tiger, Pascale; Tomas, Salvador Chemistry - A European Journal, 2002 , vol. 8, # 23 p. 5435 - 5446

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Citation Number: 24

Abstract

Abstract Chemical double-mutant cycles have been used to quantify intermolecular functional-group interactions in H-bonded zipper complexes in chloroform. If the same interaction is measured in zippers of different overall stability, the double-mutant cycles can be combined to produce a triple-mutant box. This construct quantifies cooperativity between the functional group interaction of interest and the other interactions that are used to ...