The replacement of a benzene ring of a physiologically active compound by an isosteric system such as the pyridine nucleus is a process which has led to many interesting compounds and some useful drugs2 We have made use of this principle in the preparation of the 2-pyridyl analog of the known analgesic Demerol (Meperidine). No previous report of the preparation of this compound or its 3-or 4-pyridyl isomers could be found in the ...
