A convenient synthesis of cis and trans 4-tert-butoxycarbonyl-substituted cyclohexylglycine

…, FG Njoroge, V Girijavallabhan…

Index: Venkatraman, Srikanth; Njoroge, F. George; Girijavallabhan, Viyyoor; McPhail, Andrew T. Journal of Organic Chemistry, 2002 , vol. 67, # 8 p. 2686 - 2688

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Citation Number: 5

Abstract

The nonproteinogenic amino acid cyclohexylglycine is widely found in various natural products and pharmaceutical intermediates. 1 The incorporation of these amino acids into the peptide inhibitors renders resistance from peptidases and proteinases and thereby imparts pharmacological stability to molecules. 2 In the course of our ongoing program to identify pharmaceutically active targets, we required large quantities of cis and trans substituted 4-tert-butoxycarboxyl ...