Synlett

Efficient Synthesis of Functionalized 2, 3-Di (alkenyl) benzothiophenes and Dibenzothiophenes Based on the First Heck Reactions of 2, 3-Di-and 2, 3, 6- …

M Hussain, I Malik, A Villinger, P Langer

Index: Hussain, Munawar; Malik, Imran; Villinger, Alexander; Langer, Peter Synlett, 2009 , # 16 p. 2691 - 2695

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Abstract

The Heck reaction of 2a with acrylates 3b,e (2.5 equiv) afforded the 2,3-di(alkenyl)benzothiophenes 4b,e in good yields (Scheme [²] , Table [¹] ). The best yields were obtained when the reactions were carried out using Pd(OAc) 2 (5 mol%) and the biaryl monophosphine ligand L 1 (10 mol%) which was recently developed by Buchwald and coworkers (Figure [¹] ). [²¹] The reactions were carried out in DMF at 100 ˚C for 12 hours [²²] the employment of Pd(PPh 3 ) 4 and ...