Platinum catalysed hydrosilylation of propargylic alcohols

CA McAdam, MG McLaughlin, AJS Johnston…

Index: McAdam, Catherine A.; McLaughlin, Mark G.; Johnston, Adam J. S.; Chen, Jun; Walter, Magnus W.; Cook, Matthew J. Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4488 - 4502

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Citation Number: 13

Abstract

A facile and user-friendly protocol has been developed for the selective synthesis of E-vinyl silanes derived from propargylic alcohols using a PtCl2/XPhos catalyst system. The reaction is generally high yielding and provides a single regioisomer at the β-position with E-alkene geometry. The reaction is extremely tolerant of functionality and has a wide scope of reactivity both in terms of alkynes and silanes used. The catalyst loading has been ...