Ir-catalyzed substitution of propargylic-type esters with enoxysilanes

I Matsuda, K Komori, K Itoh

Index: Matsuda, Isamu; Hasegawa, Yuki; Makino, Tatsuya; Itoh, Kenji Tetrahedron Letters, 2000 , vol. 41, # 9 p. 1405 - 1408

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Citation Number: 57

Abstract

Propargylic-type acetates react readily with enoxysilanes in the presence of 1 mol% of [Ir (cod){P (OPh) 3} 2] OTf activated preliminarily with molecular H2 to give β-alkynyl ketones in high to excellent yields. Substitution at the propargyl carbon proceeds exclusively or