Tetrahedron

Tertiary amine-based glutathione peroxidase mimics: some insights into the role of steric and electronic effects on antioxidant activity

D Bhowmick, G Mugesh

Index: Bhowmick, Debasish; Mugesh, Govindasamy Tetrahedron, 2012 , vol. 68, # 51 p. 10550 - 10560,11

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Citation Number: 11

Abstract

In this work, several tertiary amine-based diaryl diselenides were synthesized and evaluated for their glutathione peroxidase (GPx)-like antioxidant activities using hydrogen peroxide, tert-butyl hydroperoxide and cumene hydroperoxide as substrates and thiophenol (PhSH) and glutathione (GSH) as co-substrates. A comparison of the GPx-like activity of 4-methoxy- substituted N, N-dialkylbenzylamine-based diselenides with that of the corresponding 6- ...