TPGS-750-M: a second-generation amphiphile for metal-catalyzed cross-couplings in water at room temperature

…, S Ghorai, AR Abela, R Moser, T Nishikata…

Index: Lipshutz, Bruce H.; Ghorai, Subir; Abela, Alexander R.; Moser, Ralph; Nishikata, Takashi; Duplais, Christophe; Krasovskiy, Arkady; Gaston, Ricky D.; Gadwood, Robert C. Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4379 - 4391

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Citation Number: 120

Abstract

An environmentally benign surfactant (TPGS-750-M), a diester composed of racemic α- tocopherol, MPEG-750, and succinic acid, has been designed and readily prepared as an effective nanomicelle-forming species for general use in metal-catalyzed cross-coupling reactions in water. Several “name” reactions, including Heck, Suzuki− Miyaura, Sonogashira, and Negishi-like couplings, have been studied using this technology, as ...