Squalamine (1) is a novel aminosterol isolated from the dogfish shark, 1 which has been shown to possess antiangiogenic and antitumor activity. 2 Until the present time, the only practical way to obtain significant quantities of squalamine was by extraction from shark livers. However, squalamine is obtained in small amounts (0.001-0.002 wt%) at significant expense in time and materials. There have been three published syntheses of squalamine ...
