Synlett

A Concise and Cascade Synthesis of Batracylin and Substituted Isoindolo-[1, 2-b] quinazolin-12 (10H)-ones

R Shankar, MB Wagh, MV Madhubabu, N Vembu…

Index: Shankar; Wagh, Manoj Balu; Madhubabu; Vembu; Kumar, U. K. Syam Synlett, 2011 , # 6 p. 844 - 848

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Citation Number: 9

Abstract

Abstract A concise, highly convergent, and practical synthesis of the clinical-phase anticancer agent batracylin in a two-stage process in excellent yield is described. The B and C rings of this tetracyclic heterocycle are constructed by cascade cyclization of 5-nitro-2- aminobenzyl alcohol with 2-cyanomethyl benzoate in trifluoroacetic acid in good yield in a single-pot reaction. A plausible mechanism for the cascade reaction is also proposed. As ...