The reaction of alkyl aryl ketones with Oxone® and trifluoromethanesulfonic acid in the presence of iodoarene in acetonitrile, propionitrile, butyronitrile, and isobutyronitrile, provided directly the corresponding 2, 5-disubstituted and 2, 4, 5-trisubstituted oxazoles, respectively, in moderate yields. Here, reactive aryliodonium I (III) species is formed in situ by the reaction of iodoarene with Oxone® and trifluoromethanesulfonic acid, and the ...
