Synthesis and antimicrobial activity of certain 6H-1, 2, 4-oxadiazin-3 (2H)-ones

PT Berkowitz, RA Long, P Dea, RK Robins…

Index: Berkowitz,P.T. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 134 - 138

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Citation Number: 21

Abstract

Treatment of GH-1, 2, 4-oxadiazin-3 (2H)-one-5 (4H)-thione (2) with hydroxylamine, hydrazine, methylamine, or benzylamine afforded the corresponding N5-substituted 5-amino- GH-1, 2, 4-oxadiazin-3 (2H)-ones 3c-f. Refluxing a dioxane solution of GH-1, 2, 4-oxadiazine- 3, 5 (2H, 4H)-dione (1) with benzylamine or aminodiphenylmethane and hexamethyldisilazane in the presence of ammonium sulfate gave 5-benzylamino-GH-l, 2, ...