Syntheses, radiolabelings, and in vitro evaluations of fluorinated PET radioligands of 5-HT6 serotoninergic receptors

J Colomb, G Becker, S Fieux, L Zimmer…

Index: Journal of Medicinal Chemistry, , vol. 57, # 9 p. 3884 - 3890

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Citation Number: 13

Abstract

... Journal of Medicinal Chemistry. ... In 2005, a pharmaceutical company patented a new generation of 5-HT 6 receptor antagonists based on the 3-benzenesulfonyl-8-piperazine-1-ylquinoline scaffold.(18) Within this scaffold, N-methyl derivative 1 presented high binding affinity ...