Tetrahedron

Expanding the application scope of glycosidases using click chemistry

WY Lu, XW Sun, C Zhu, JH Xu, GQ Lin

Index: Lu, Wen-Ya; Sun, Xing-Wen; Zhu, Chen; Xu, Jian-He; Lin, Guo-Qiang Tetrahedron, 2010 , vol. 66, # 3 p. 750 - 757

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Citation Number: 18

Abstract

Glycosidase-mediated glycosylation of alkynyl alcohols and azide-containing alcohols was followed by a click reaction, affording various types of triazole glycosides. The activities of triazole glycosides detected in subsequent bioassays show that this procedure is a feasible approach to the development of anti-fungal drugs.