Transformation of poorly water-soluble drugs into lipophilic ionic liquids enhances oral drug exposure from lipid based formulations

Y Sahbaz, HD Williams, TH Nguyen…

Index: Williams, Hywel D.; Sahbaz, Yasemin; Ford, Leigh; Nguyen, Tri-Hung; Scammells, Peter J.; Porter, Christopher J. H. Chemical Communications, 2014 , vol. 50, # 14 p. 1688 - 1690

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Citation Number: 18

Abstract

Absorption after oral administration is a requirement for almost all drug products but is a challenge for drugs with intrinsically low water solubility. Here, the weakly basic, poorly water-soluble drugs (PWSDs) itraconazole, cinnarizine, and halofantrine were converted into lipophilic ionic liquids to facilitate incorporation into lipid-based formulations and integration into lipid absorption pathways. Ionic liquids were formed via metathesis ...