Benzidine, an aromatic diamine, induces bladder tumors in man and dog, and predominately liver tumors in rat (1-4). One distinguishing characteristic between rat and dog arylamine metabolism is that the former has been considered an acetylator, and the latter a nonacetylator (5, 6). In rats, benzidine is rapidly acetylated to N-acetylbenzidine and NJV'-diacetylbenzidine (7). Following administration of benzidine to mice and rats and N- ...
