Bioorganic & medicinal chemistry

Determination of the phamacophore of penclomedine, a clinically-evaluated antitumor pyridine derivative

A Tiwari, WR Waud, RF Struck

Index: Tiwari, Anita; Waud, William R; Struck, Robert F Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 11 p. 3593 - 3598

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Citation Number: 15

Abstract

The main objective of this investigation was to identify the reactive pharmacophore in penclomedine (PEN, 3, 5-dichloro-4, 6-dimethoxy-2-(trichloromethyl) pyridine) for in vivo antitumor activity and also to discover related ring structures and sulfur analogues that ...