Mild and safer preparative method for nonsymmetrical sulfamides via N-sulfamoyloxazolidinone derivatives: Electronic effects affect the transsulfamoylation reactivity

…, JP Van Hoeck, A Mockel, A Merschaert

Index: Borghese; Antoine; Van Hoeck; Mockel; Merschaert Organic Process Research and Development, 2006 , vol. 10, # 4 p. 770 - 775

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Citation Number: 17

Abstract

Sulfamides (R1R2N-SO2-NR3R4) are traditionally prepared by using strong electrophilic and hazardous reagents such as N-sulfamoyl chloride, sulfonyl chloride, phosphorus oxychloride, or phosphorus pentachloride. We report here a safer and more convenient synthetic methodology for large-scale preparation of sulfamides using the N-substituted oxazolidin-2-one derivatives 5 as synthetic equivalent of the corrosive and hazardous N- ...