Dicationic dibenzofuran derivatives as anti-Pneumocystis carinii pneumonia agents: synthesis, DNA binding affinity, and anti-P. carinii activity in an …

…, JE Hall, FA Tanious, WD Wilson, DA Patrick…

Index: Wang, Sihe; Hall, James Edwin; Tanious, Farial A.; Wilson, W. David; Patrick, Donald A.; McCurdy, Donald R.; Bender, Brenden C.; Tidwell, Richard R. European Journal of Medicinal Chemistry, 1999 , vol. 34, # 3 p. 215 - 224

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Citation Number: 24

Abstract

Previous work from our laboratory shows that compounds with two cations linked by a carbazole spacer were highly potent antiP. carinii agents. A prodrug approach designed to increase oral activity of the dicationic carbazoles by converting amidine groups to amidoxime groups was unsuccessful. The ring nitrogen was implicated as playing a role in the lack of activity of carbazole amidoximes. The current study was designed to determine ...