The Journal of Organic Chemistry

Synthesis of. alpha.-methoxyaliphatic acids from chloroform and aliphatic aldehydes with sodium hydride as catalyst in tetrahydrofuran

EL Compere Jr, A Shockravi

Index: Compere,E.L.; Shockravi,A. Journal of Organic Chemistry, 1978 , vol. 43, p. 2702 - 2703

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Citation Number: 2

Abstract

The preparations of a-methoxyaliphatic acids, which we report here, have not been reported previously by any other method. A number of earlier articles have reported the con- densation of chloroform (or bromoform) with aryl aldehydes to produce either aryl trihalomethyl-substituted methanols' or the products of the reaction of such alcohols2 with base and/or solvent. In the latter cases, a-substituted arylacetic acids are often produced, ...