Journal of medicinal chemistry

Synthetic carboxyl-containing polyethers, analogs of natural antibiotics

JO Gardner, CC Beard

Index: Gardner,J.O.; Beard,C.C. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 357 - 361

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Citation Number: 16

Abstract

The monocarboxylic acid polyether antibiotics have recently been reviewed. 2 The antibiotics have the ability to form lipophilic complexes with a variety of organic and inorganic cations. The inner surface of these materials consists of an array of oxygen atoms present in ether, hydroxyl, or carbonyl groups while the outer surface is composed of hydrophobic alkyl groups. There is evidence that these complexes act as carriers, ...