Abstract A series of acyclic and heterocyclic analogues of carbacholine (1) was synthesized using N-methylcarbacholine (MCC, 2), N, N-dimethylcarbacholine (DMCC, 3), and the corresponding tertiary amine (4) as leads. Whereas nicotinic acetylcholine receptor affinity was determined using [3 H] nicotine as the radioactive ligand,[3 H] oxotremorine-M ([3 H] Oxo-M) and [3 H] quinuclidinyl benzilate ([3 H] QNB), in some cases supplemented with [3 ...
