A convenient synthesis of new pyrido [3, 2-e][1, 4] diazepine-2, 5-diones and pyrido [2, 3-e][1, 4] diazepine-2, 5-diones

…, S Lazar, M Akssira, MC Viaud-Massuard

Index: El Bouakher, Abderrahman; Laborie, Helne; Aadil, Mina; El Hakmaoui, Ahmed; Lazar, Said; Akssira, Mohamed; Viaud-Massuard, Marie-Claude Tetrahedron Letters, 2011 , vol. 52, # 39 p. 5077 - 5080

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Citation Number: 5

Abstract

A convenient synthesis of a series of pyrido [3, 2-e][1, 4]-diazepine-2, 5-diones 8 and pyrido [2, 3-e][1, 4] diazepine-2, 5-diones 9, is reported using the condensation of α-amino acid methyl ester derivatives with 1H-pyrido [3, 2-d][1, 3] oxazine-2, 4-dione and 1H-pyrido [2, 3- d][1, 3] oxazine-2, 4-dione. Compounds 8 and 9 were also synthesized by peptide coupling of α-amino acid methyl ester derivatives with β-amino acids (2 or 3) followed by the ...