Tetrahedron letters

New cleavable isocyanides for the combinatorial synthesis of α-amino acid analogue tetrazoles

…, M Umkehrer, C Kalinski, G Ross, J Kolb, C Burdack…

Index: Mayer, Josef; Umkehrer, Michael; Kalinski, Cedric; Ross, Guenther; Kolb, Juergen; Burdack, Christoph; Hiller, Wolfgang Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7393 - 7396

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Citation Number: 30

Abstract

3-Substituted 3-isocyano propionates as new cleavable isocyanides in combinatorial tetrazole synthesis via Ugi-reaction are introduced. The obtained 5-substituted tetrazoles are transformed into carboxylic acid isosteric 5-substituted 1H-tetrazoles under basic cleavage conditions.