Studies on peptides. CXLVIII Application of a new deprotecting procedure with trimethylsilyl trifluoromethanesulfonate for the syntheses of two porcine spinal cord …

…, T SEGAWA, Y NAKATA, A INOUE, H YAJIMA

Index: Fujii; Ikemura; Funakoshi; Matsuo; Segawa; Nakata; Inoue; Yajima Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 3 p. 1076 - 1084

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Citation Number: 6

Abstract

The usefulness of a new deprotecting procedure was demonstrated in the solution syntheses of two porcine spinal cord peptides, designated neuromedin U-8 and neuromedin U-25. Protected neuromedin U-8 (8-residue peptide), prepared by condensation of two fragments, served as a C-terminal amino component for the synthesis of neuromedin U-25 (25-residue peptide). Onto this fragment, five peptide fragments were successively ...