Efficient synthesis of 1, 3, 5-oxygenated synthons from dimethyl 3-oxoglutarate: first use of borane-dimethyl sulfide complex as a regioselective reducing agent …

VB Riatto, MNM Carneiro, VB Carvalho…

Index: Riatto, Valeria B.; Carneiro, Maria N. M.; Carvalho, Venilia B.; Victor, Mauricio M. Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 1 p. 172 - 175

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Abstract

The selective reduction of dimethyl 3-oxoglutarate was accomplished in different levels. A high yielding sodium borohydride reduction of the keto group is fully described leading to dimethyl 3-hydroxyglutarate. When borane-dimethyl sulfide (BMS) complex was used, a ...