II. Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent, 2-{4-[(7-chloro-2-quinoxalinyl) oxy] phenoxy} propionic acid (XK469 …

ST Hazeldine, L Polin, J Kushner, K White…

Index: Hazeldine, Stuart T.; Polin, Lisa; Kushner, Juiwanna; White, Kathryn; Bouregeois, Nicole M.; Crantz, Brianna; Palomino, Eduardo; Corbett, Thomas H.; Horwitz, Jerome P. Journal of Medicinal Chemistry, 2002 , vol. 45, # 14 p. 3130 - 3137

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Citation Number: 81

Abstract

XK469 (1) is among the most highly and broadly active antitumor agents to have been evaluated in our laboratories. Subsequent developmental studies led to the entry of (R)-(+) 1 (NSC 698215) into phase 1 clinical trials (NIH UO1-CA62487). The antitumor mechanism of action of 1 remains to be elucidated, which has prompted a sustained effort to elaborate a pharmacophoric pattern of 1. The present study focused on a strategy of synthesis and ...