A series of 5, 5-diarylpenta-2, 4-dienoic acids and their amides have been synthesized and evalriated as antimalarial agents. The acids were prepared from the corresponding diary1 ketones either directly by a Refor-matsky procedure or through acetylenic alcohol and acrolein intermediates. The preparation of a series of 3, s-bis (4-chloropheny1) acrylic acid amides is also reported. One compound, IVjPi-diethyl-5, 5-bis (4-chloropheny1)-penta-2, 4 ...
