e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Transformations of 1, 2, 4-Triazines in Reactions with Nucleophiles: V. SNH and ipso-Substitution in the Synthesis and Transformations of 5-Cyano-1, 2, 4-triazines
Abstract The scope of functionalization of 1, 2, 4-triazines can be considerably extended via successive nucleophilic substitution of hydrogen (SNH) and ipso-substitution. A convenient procedure has been developed for direct cyanation of 1, 2, 4-triazine 4-oxides with acetone cyanohydrin in the presence of triethylamine. The cyano group in the resulting 5-cyano-1, 2, 4-triazines is readily replaced by reactions with various aliphatic alcohols and amines.
