Chemistry Letters

Condensation of. ALPHA.-Amino Acid with Amine in the Absence of a Coupling Agent

J Yamaguchi, S Nagai, E Fukuoka, T Suyama

Index: Yamaguchi, Jun-Ichi; Nagai, Shinya; Fukuoka, Emi; Suyama, Takayuki Chemistry Letters, 2003 , vol. 32, # 9 p. 830 - 831

Full Text: HTML

Citation Number: 2

Abstract

4-Nitrophenyl N-substituted carbamate is known as a pre- cursor of isocyanate1 and is utilized in the synthesis of multi- substituted urea.2 On the other hand, isocyanate reacts with some nucleophiles such as carboxamide3 and carboxylic acid4 to afford N-acylurea or carboxamide, respectively. From the above reports, we assumed that treatment of N-(4-nitrophen- oxycarbonyl)amino acid (Npoc-AA-OH) with amine generated 2-isocyanatocarboxylic ...