Conformationally Constrained Analogues of Diacylglycerol. 13. 1 Protein Kinase C Ligands Based on Templates Derived from 2, 3-Dideoxy-l-erythro (threo)-hexono-1, …

J Lee, NE Lewin, P Acs, PM Blumberg…

Index: Lee, Jeewoo; Lewin, Nancy E.; Acs, Peter; Blumberg, Peter M.; Marquez, Victor E. Journal of Medicinal Chemistry, 1996 , vol. 39, # 25 p. 4912 - 4919

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Citation Number: 12

Abstract

In the present investigation, the last two possible modes of generating conformationally semirigid diacylglycerol (DAG) analogues embedded into five-membered ring lactones as templates III and IV are investigated. The first two templates studied in previous investigations corresponded to 2-deoxyribonolactone (template I) and 4, 4-disubstituted γ- butyrolactone (template II), with the latter producing potent protein kinase C (PK-C) ...