Adenosine Deaminase Inhibitors: Synthesis and Biological Evaluation of Unsaturated, Aromatic, and Oxo Derivatives of (+)-e rythro-9-(2'S-Hydroxy-3'R-nonyl) …

PVP Pragnacharyulu, V Varkhedkar…

Index: Pragnacharyulu; Varkhedkar; Curtis; Chang; Abushanab Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4694 - 4700

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Citation Number: 19

Abstract

The synthesis and biological evaluation of three classes of chain-modified derivatives of (+)- EHNA are described. Among the 5', 6'-unsaturated derivatives, the Z-isomer was the most potent inhibitor of adenosine deaminase (ADA) but 3-fold less active than (+)-EHNA. Several 9-aralkyladenines (ARADs) have been prepared, and their inhibitory activity was determined. A minimum of two carbon atoms separating the aromatic ring from the ...