e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Liebigs Annalen
Enzymes in organic synthesis. Expedient enantioselective synthesis of (S)??(−)??3, 4??dihydroxybutylphosphonate, an isosteric substrate mimic for glycerol phosphate …
Abstract The title compound (S)-(−)-2 was obtained in enantiomerically pure form and 47% overall yield starting from (S)-malic acid (S)-7 by a 5-step sequence involving reduction to (S)-1, 2, 4-butanetriol (S)-8, acetalization, and introduction of the phosphonate group by an Arbusow reaction. Compound (S)-(−)-2 is a substrate for the L-glycerol 3-phosphate oxidase from Pediococcus sp. which quantitatively converts it into 4-hydroxy-3- ...
