Organic letters

A New Strategy for Construction of Eight-Membered Carbocycles by Brook Rearrangement Mediated [6+ 2] Annulation

K Takeda, H Haraguchi, Y Okamoto

Index: Takeda, Kei; Haraguchi, Hidekazu; Okamoto, Yasushi Organic Letters, 2003 , vol. 5, # 20 p. 3705 - 3707

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Citation Number: 17

Abstract

A newly developed strategy for construction of eight-membered carbocycles via [6+ 2] annulation that involves the combination of β-alkenoyl acylsilanes and a vinyllithium derivative is described. A unique feature of this annulative approach is that it enables in one operation and a stereoselective manner construction of eight-membered ring systems containing useful functionalities for further synthetic elaboration from readily available six- ...