Abstract A method for conducting enantioselective bromolactonization reactions of trisubstituted alkenoic acids, using the C 3-symmetric trisimidazoline 1 and 1, 3-dibromo-5, 5- dimethyl hydantoin as a bromine source, has been developed. The process generates chiral δ-lactones that contain a quaternary carbon. The results of studies probing geometrically different olefins show that (Z)-olefins rather than (E)-olefins are favorable substrates for the ...
