The Journal of organic chemistry

Chirospecific synthesis of spirocyclic β-lactams and their characterization as potent type ii β-turn inducing peptide mimetics

H Bittermann, P Gmeiner

Index: Easton, Christopher J.; Love, Stephen G.; Wang, Peng Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 277 - 282

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Citation Number: 73

Abstract

... The Journal of Organic ... and evaporated, and the residue was purified by column chromatography (hexanes/ethyl acetate 6:1 increasing to 3:1), furnishing 14.4 g (65%) of 6 ... cm - 1 ; 1 H NMR (360 MHz, CDCl 3 ) δ 1.80−1.91 (m, 1H), 1.92−2.03 (m, 1H), 2.29 (ddd, 1H, J = 13.4, 6.7 ...