Tetrahedron

The synthesis and chemical reactivity of 3-chloro-6-(2-pyrrolyl) pyridazine

RA Jones, AP Whitmore

Index: Jones, R. Alan; Whitmore, Alexander P. Tetrahedron, 1998 , vol. 54, # 33 p. 9519 - 9528

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Citation Number: 12

Abstract

3, 6-Dichloropyridazine and 1-alkyl-3, 6-dichloropyridazinium cations react with pyrrolylmagnesium bromide to produce 3-chloro-6-(2-pyrrolyl) pyridazine. Further reaction with other nucleophiles is slow, but is enhanced by quaternisation of the 2-N atom. 3, 6-Di (2- pyrrolyl) pyridazine could not be obtained by this route.