Diamine-based human histamine H 3 receptor antagonists:(4-Aminobutyn-1-yl) benzylamines

CA Dvorak, R Apodaca, W Xiao, JA Jablonowski…

Index: Dvorak, Curt A.; Apodaca, Richard; Xiao, Wei; Jablonowski, Jill A.; Bonaventure, Pascal; Dugovic, Christine; Shelton, Jonathan; Lord, Brian; Miller, Kirsten; Dvorak, Lisa K.; Lovenberg, Timothy W.; Carruthers, Nicholas I. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4098 - 4106

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Citation Number: 9

Abstract

A series of (4-aminobutyn-1-yl) benzylamines were prepared and the SAR around three key areas:(1) the amine attached to the butynyl linker (R3R4N–);(2) the benzylamine moiety (R1R2N–); and (3) the point of attachment of the benzylamine group (R1R2N–in the ortho, ...