Prominent inclusion effect of dimethyl?螃漫?cyclodextrin on photoisomerization of the thromboxane synthetase inhibitor (E)??4??(1??imidazoylmethyl) cinnamic acid

…, K Uekama, M Yamasaki, K Harata

Index: Hirayama; Utsuki; Uekama; Yamasaki; Harata Journal of Pharmaceutical Sciences, 1992 , vol. 81, # 8 p. 817 - 822

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Citation Number: 13

Abstract

Abstract The direct photoisomerization of (E)-4-(1-imidazoylmethyl)-cinnamic acid (IMC), a thromboxane synthetase inhibitor, to its (Z)-isomer at pH 2.0 was decelerated by β- cyclodextrin (β-CyD) and heptakis (2, 6-di-O-methyl)-β-cyclodextrin (DM-β-CyD). The photostationary composition [(Z)-isomer: IMC ratio] was shifted in favor of IMC. These effects were much greate: with DM-β-CyD than with the parent β-CyD. The quantum yield of the ...