Sequential onepot addition of alkylpyrazines, alkynes, and a proton source to a solution of Cp, Zr (Me)(THF)+(1) in CHzClz at room temperature affords (E!)-alkenyl-substituted alkylpyrazines 2-10 in excellent yields. The regio-and stereoselectively observed in these reactions is similar to those observed previously for related early transition metal-mediated reactions and is ascribed to steric and Si electronic effects. Conventional synthetic organic ...
