New. MU.-Opioid Receptor Agonists with Phenoxyacetic Acid Moiety.

…, Y Kanamaru, N Kawamoto, T Okada, T Kaiho…

Index: Sato, Susumu; Komoto, Teruo; Kanamaru, Yoshihiko; Kawamoto, Noriyuki; Okada, Tomomi; Kaiho, Terumitsu; Mogi, Kinichi; Morimoto, Shinichi; Umehara, Norimitsu; Koda, Tadayuki; Miyashita, Akira; Sakamoto, Takao; Niino, Yasuhiro; Oka, Tetsuo Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 2 p. 292 - 297

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Citation Number: 9

Abstract

New μ-opioid receptor (MOR) agonists containing 4-hydroxypiperidine, piperidine and piperazine moieties were synthesized and evaluated to find a peripheral opioid analgesic. Among the synthesized compounds,[2-[1-[3-(N, N-dimethylcarbamoyl)-3, 3-diphenylpropyl]- 4-hydroxypiperidin-4-yl] phenoxy] acetic acid (8: SS620) having phenoxyacetic acid and 4- hydroxypiperidine moieties showed the highest agonist potency on the MOR in an ...

Synthesis of N-substituted 4-(4-hydroxyphenyl) piperidines, ...

[Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; Cai, Sui Xiong; Hawkinson, Jon E.; Keana, John F. W.; Kesten, Suzanne R.; Shipp, Christina T.; Tran, Minhtam; Whittemore, Edward R.; Woodward, Richard M.; Wright, Jon L.; Zhou, Zhang-Lin Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 984 - 994]