Tetrahedron letters

Solution phase synthesis of imidazo [1, 2-b] pyrazol-2-one, an interesting 5, 5-fused heterocyclic ring system

…, A Srivastava, KR Coburn, AL Faulkner, JJ Janusz…

Index: Blass, Benjamin E.; Srivastava, Anil; Coburn, Keith R.; Faulkner, Amy L.; Janusz, John J.; Ridgeway, James M.; Seibel, William L. Tetrahedron Letters, 2004 , vol. 45, # 3 p. 619 - 621

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Citation Number: 10

Abstract

The solution phase synthesis of a series of imidazo [1, 2-b] pyrazol-2-ones, a fused 5, 5-ring system, based on diverse set of hydrazino acids and malononitriles is described. The method involves formation of 5-aminopyrazoles followed by intra-molecular cyclodehydration.