Abstract The synthesis of various polycyclic systems containing aC 3a–N i bond between a hexahydropyrrolo [2, 3-b] indole and an indole tryptophan is described here. A series of experiments were performed to determine the best combination of five orthogonal protecting groups and the best reaction conditions for formation of said bond, which is a common feature among many recently discovered marine natural products.
![dimethyl (2S,3aS,8bR)-4-(benzenesulfonyl)-1,2,3a,8b-tetrahydropyrrolo[2,3-b]indole-2,3-dicarboxylate Structure](https://image.chemsrc.com/caspic/315/136057-11-9.png)