Substituted dibenzo [c, h] cinnolines: Topoisomerase I-targeting anticancer agents

…, SK Singh, A Liu, TK Li, LF Liu, EJ LaVoie

Index: Yu, Younong; Singh, Sudhir K.; Liu, Angela; Li, Tsai-Kun; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1475 - 1491

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Citation Number: 51

Abstract

Several substituted dibenzo [c, h] cinnolines were synthesized and evaluated for their potential to target topoisomerase I and for their relative cytotoxic activity. Select benzo [i] phenanthridines are capable of stabilizing the cleavable complex formed with topoisomerase I and DNA. This study was initiated to examine whether dibenzo [c, h] cinnolines, which are in essence aza analogues of benzo [i] phenanthridines, possess ...