Abstract The synthesis and the nidation inhibitory activity (indirect evidence of prolactin activity) of a new class of ergolinyl-acylureas is described. Some structure—activity relationship considerations are also reported. N-[3-(Dimethyl-amino) propyl]-N-[(ethylamino) carbonyl]-6-(2-propenyl) ergoline-8β-carboxamide (laboratory code FCE 21336; international non-proprietary name cabergoline) was the most interesting compound of ...