Stereochemical diversity of AI-2 analogs modulates quorum sensing in Vibrio harveyi and Escherichia coli

…, JC Marques, ST Miller, CD Maycock, KB Xavier…

Index: Rui, Fabio; Marques, Joao C.; Miller, Stephen T.; Maycock, Christopher D.; Xavier, Karina B.; Ventura, M. Rita Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 249 - 256

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Citation Number: 11

Abstract

Bacteria coordinate population-dependent behaviors such as virulence by intra-and inter- species communication (quorum sensing). Autoinducer-2 (AI-2) regulates inter-species quorum sensing. AI-2 derives from the spontaneous cyclisation of linear (S)-4, 5- dihydroxypentanedione (DPD) into two isomeric forms in dynamic equilibrium. Different species of bacteria have different classes of AI-2 receptors (LsrB and LuxP) which bind to ...