1, 2-Dihydro-1-oxopyrrolo [3, 2, 1-kl] phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with anti-inflammatory activity

…, TJ Carty, PF Moore, WJ Zembrowski

Index: Mylari, Banavara L.; Carty, Thomas J.; Moore, Peter F.; Zembrowski, William J. Journal of Medicinal Chemistry, 1990 , vol. 33, # 7 p. 2019 - 2024

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Citation Number: 28

Abstract

A series of 1, 2-dihydro-l-oxopyrrolo [3, 2, l-kl] phenothiazine, 1, 2-dihydro-l-oxopyrrolo [3, 2, 1-kl] phenoxazine, and 1, 2-dihydro-l-oxopyrrolo [3, 2, l-~ e] acridine-2-carboxamides were prepared by reaction of 1, 2-dihydro-l-oxo-pyrrolo [3, 2, l-kl] phenothiazine or other corresponding phenoxazine and acridan ethyl or methyl esters with appropriate amines. Several members of this family were found to be potent, dual inhibitors of cyclooxygenase ...