Archiv der Pharmazie

Electron Impact Induced Loss of C??5/C??8 Substituents of 1, 2, 3, 4??Tetrahydroisoquinolines, V: Synthesis and Mass Spectrometric Fragmentation of Dihydroisoindole …

F Knefeli, KK Mayer, W Wiegrebe

Index: Knefeli, Frank; Mayer, Klaus K.; Wiegrebe, Wolfgang Archiv der Pharmazie (Weinheim, Germany), 1989 , vol. 322, p. 419 - 426

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Abstract

Abstract C-8-substituted N-methyl-1, 2, 3, 4-tetrahydroisoquinoline radical cations lose the complete substituent in a one step reaction giving rise to an unexpected ion at m/z 146, which is probably identical with the dihydroisoindolyl-methyl-cation A. The dihydroisoindoles 1, 10, and 16 were prepared as potentially alternative precursors of ion A. However, the ion at m/z 146 in their El mass spectra is of very low intensity, so CID-experiments for ...