The nitrosation of various thiols and morpholine by oxygenated NO solutions at physiological pH was investigated. The formation rates and the yields of the nitroso compounds were determined using the stopped-flow technique. The stoichiometry of this process has been determined, and is given by 4NO+ O2+ 2RSH/2RR'NH→ 2RSNO/2RR'NNO+ 2NO2-+ 2H+. Kinetic studies show that the rate law is-d [O2]/dt= k 1 [ ...
